Scientists are pioneering advanced agricultural technologies tailored to support food production for astronauts during extended expeditions to the Moon and Mars. By integrating plant science, engineering expertise, and nutrient recycling systems, they aim to establish closed-loop farming solutions suitable for the harsh conditions of space where conventional farming isn’t viable.
Designing Plant Growth Systems for Harsh Space Conditions
Exploration beyond Earth requires novel agricultural solutions since habitats on spacecraft or other planets must operate within tight resource and space limits while enduring extreme environmental factors. Teams at the University of South Florida’s Aerospace Science, Technology, Research and Applications Center (ASTRA) are investigating how plants, microbes, and biological communities respond to simulated extraterrestrial conditions.
This research largely occurs in controlled labs on Earth, where scientists replicate the temperature shifts, atmospheric compositions, light cycles, and nutrient availability found in space environments. Collaborators from engineering, botany, and medical fields join forces to develop technologies that not only benefit astronauts but also offer solutions to terrestrial environmental issues.
“We’re building multidisciplinary teams of engineers, plant scientists and health researchers who are contributing to space-related projects and their applications on Earth. It’s creating an opportunity for USF to establish itself as a leader in this field,” said Stephanie Carey, associate professor and principal investigator for USF’s ASTRA Center.
The focus revolves around crafting sustainable agricultural setups capable of long-term functionality far from Earth. As missions extend over months or years, astronauts will need to cultivate their own crops, reducing reliance on Earth-supplied provisions. These farming systems must operate autonomously and efficiently recycle vital resources.

Lessons from Mangroves for Extraterrestrial Agriculture
Led by Christina Richards, associate professor of integrative biology at USF, the research team studies resilient plants thriving in Earth’s most challenging coastal environments, including red mangroves and Spartina alterniflora marsh grass. These species have adapted to fluctuating water chemistry, pollution, and salinity in ways that could inform space-based farming.
Researchers analyze how such plants regulate stress responses and interact with root-associated microbes to sustain growth. The biological methods these coastal plants use to endure tough conditions may help optimize crop growth in controlled habitats on other worlds.
The connection between coastal ecosystems and extraterrestrial agriculture grew when graduate student Jessica Bains considered how plant biology might be applied to space environments. Richards identified an opportunity to apply genomic tools to decode plant adaptations under resource scarcity and unstable conditions.
“Space agriculture is about understanding how to grow plants in extremely difficult environments,” Richards said. “At first, I saw this topic as an opportunity to apply our approaches in genomics to understand how plants regulate those responses under the stresses they face in extraterrestrial environmental conditions.”
The team approaches space farming as a scientific discipline grounded in biological principles rather than merely a technical challenge. Their aim is to unravel plant resilience mechanisms before tailoring these insights for use in spacecraft and planetary greenhouses.
“We want this to be rigorous science, not simply excitement about doing ‘space work,'” Richards said. “The goal is to start with strong plant biology grounded in Earth-based systems before expanding to agriculture and true space growth conditions.”

Transforming Waste Into Growth Resources for Space
Future lunar and Martian habitats will require efficient waste recycling to convert human byproducts into usable materials. Professor Daniel Yeh leads the Membrane Biotechnology Lab focused on developing systems that extract nutrients from waste to nourish crops.
This technology utilizes anaerobic microbes to break down waste and generate a nutrient-laden liquid that acts as a fertilizer substitute. The lab has successfully cultivated bok choy hydroponically using this recycled nutrient solution.
This innovation tackles a critical challenge of long-term space travel: minimizing cargo from Earth. Every kilogram launched into orbit or beyond raises costs, making onsite recycling indispensable.
“Launching materials into space is extremely costly, and every pound counts,” explained Alexandra Smith, graduate student in the Yeh lab. “By converting waste nutrients back into crop-growing inputs, we support astronauts on lengthy missions while also addressing wastewater issues on Earth.”
USF’s research bridges space exploration and Earth’s environmental needs, creating decentralized wastewater treatments for communities lacking infrastructure.
“Over two decades, our lab developed off-grid wastewater treatment and resource recovery solutions, including the NEWgenerator used in India and South Africa,” Yeh noted. “Our innovations caught NASA’s attention, leading to an eight-year partnership with Kennedy Space Center to adapt membrane bioreactor technologies for future lunar bases.”

Growing Plants in Orbit with CubeSats
Scientists are utilizing compact satellites called CubeSats to examine plant growth under actual spaceflight conditions. These miniature labs incorporate automated sensors, cameras, and environmental controls to monitor plant responses in orbit.
Professor Arash Takshi has spearheaded development of these CubeSat experiments, initially focused on red romaine lettuce. The technology has advanced to track multiple environmental variables impacting biological performance.
Results reveal the delicate sensitivity of plants to alterations in gas concentrations, humidity, moisture, and light. Maintaining optimal growth conditions on spacecraft involves managing these interconnected factors precisely.
The research has extended to fungi investigation, recognizing their rapid growth and resilience under radiation and tough conditions, potentially valuable for future missions.
By uniting plant biology, engineering, and sustainability science, researchers are laying the technological and scientific groundwork to support growing food beyond Earth. Their work could sustain crews on Moon, Mars, and other space expeditions, while also feeding innovations to improve Earth’s ecological footprint.
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